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Elsevier Microbiol*: Streptococcus pneumoniae pep27mutant as a live vaccine for serotype-independent protection in mice [Vaccine]
7 December 2011, 5:03 pm
Elsevier Microbiol*
Streptococcus pneumoniae pep27mutant as a live vaccine for serotype-independent protection in mice [Vaccine]
December 7
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Publication year: 2011 Source: Vaccine, Available online 7 December 2011 Eun-Hye Kim, Sang-Yoon Choi, Min-Kyoung Kwon, Thao Dang-Hien Tran, Kwang-Jun Lee, ... Streptococcus pneumoniae(pneumococcus) is responsible for significant morbidity and mortality in worldwide. After introduction of current pneumococcal vaccines, a marked decrease in the incidence of pneumococcal disease was observed. Unfortunately, serotype shifts in carriage and disease, including capsular switch and presence of antimicrobial resistance, have been found. Here we report live attenuated vaccine strain which is
avirulent and can protect from systemic and mucosal pneumococcal diseases. Pep27, an autolysis-inducing factor ofS. pneumoniaeis known to mediate LytA-dependent and -independent lysis and it was thus expected to effect virulence. The loss of Pep27 had a much larger than expected decrease in virulence and has made thePep27mutant strain sufficiently
avirulent to be used as a live vaccine. Thepep27mutation... - Elsevier Microbiol*
