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Real Time - authors
The RIP140 Gene Is a Transcriptional Target of E2F1.
26 May 2012, 5:33 am
Transcription and Chromatin
The RIP140 Gene Is a Transcriptional Target of E2F1. - http://www.ncbi.nlm.nih.gov/entrez...
3 minutes ago
from pubmed: plos chromatin and...
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The RIP140 Gene Is a Transcriptional Target of E2F1. PLoS One. 2012;7(5):e35839 authors: Docquier A, Augereau P, Lapierre M, Harmand PO, Badia E, Annicotte JS, Fajas L, Cavaillès V Abstract RIP140 is a transcriptional coregulator involved in energy homeostasis and ovulation which is controlled at the transcriptional level by several nuclear receptors. We demonstrate here that RIP140 is a novel target gene of the E2F1 transcription factor. Bioinformatics analysis, gel shift assay, and chromatin immunoprecipitation demonstrate that the RIP140 promoter contains bona fide E2F response elements. In transiently transfected MCF-7 breast cancer cells, the RIP140 promoter is transactivated by overexpression of E2F1/DP1. Interestingly, RIP140 mRNA is finely regulated during cell cycle progression (5-fold increase at the G1/S and G2/M transitions). The positive regulation by E2F1 requires sequences located in the proximal region of the promoter (-73/+167), involves Sp1 transcription factors, and... - Steve Koch
HeT-A_pi1, a piRNA Target Sequence in the Drosophila Telomeric Retrotransposon HeT-A, Is Extremely Conserved across Copies and Species.
26 May 2012, 5:33 am
Telomere Biology
HeT-A_pi1, a piRNA Target Sequence in the Drosophila Telomeric Retrotransposon HeT-A, Is Extremely Conserved across Copies and Species. - http://www.ncbi.nlm.nih.gov/entrez...
3 minutes ago
from pubmed: telomere biology...
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HeT-A_pi1, a piRNA Target Sequence in the Drosophila Telomeric Retrotransposon HeT-A, Is Extremely Conserved across Copies and Species. PLoS One. 2012;7(5):e37405 authors: Petit N, Piñeyro D, López-Panadès E, Casacuberta E, Navarro A Abstract The maintenance of the telomeres in Drosophila species depends on the transposition of the non-LTR retrotransposons HeT-A, TAHRE and TART. HeT-A and TART elements have been found in all studied species of Drosophila suggesting that their function has been maintained for more than 60 million years. Of the three elements, HeT-A is by far the main component of D. melanogaster telomeres and, unexpectedly for an element with an essential role in telomere elongation, the conservation of the nucleotide sequence of HeT-A is very low. In order to better understand the function of this telomeric retrotransposon, we studied the degree of conservation along HeT-A copies. We identified a small sequence within the 3' UTR of the element that is extremely... - Steve Koch
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