Elsevier Microbiol*: The adjuvanticity of Chiococca alba saponins increases with the length and hydrophilicity of their sugar chains [Vaccine]
11 April 2012, 8:25 am
Elsevier Microbiol* The adjuvanticity of Chiococca alba saponins increases with the length and hydrophilicity of their sugar chains [Vaccine] April 11 from Primary Resources in... - Comment - Like Publication year: 2012 Source:Vaccine, Volume 30, Issue 21 Dirlei Nico, Ricardo Moreira Borges, Layza Mendes Brandão, Daniel Ferreira Feijó, Daniele Crespo Gomes, Marcos Palatnik, Mauricio Martins Rodrigues, Antonio Jorge Ribeiro da Silva, Clarisa Beatriz Palatnik-de-Sousa The saponins of Chiococca alba are triterpene bidesmosides that contain glycidic moieties attached to the C-3 and C-28 carbon of their aglycone. We describe that their adjuvant potential increases in direct relationship to the length and hydrophilicity of the C-28 attached sugar chain which contains: arabinose–rhamnose in the CA2, arabinose–rhamnose–xylose in the CA3X; arabinose–rhamnose–apiose in the CA3 and arabinose–rhamnose–apiose–apiose in the CA4 saponin. The hydrophile/lipophile balance calculated for CA2 was 12.7, for CA3 and CA3X was 15.8 and for CA4 19.9. All saponins were formulated with the FML antigen for mice prophylaxis against visceral leishmaniasis. The immune response was studied using an... - Elsevier Microbiol*